Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers
نویسندگان
چکیده
منابع مشابه
Intermittent vs continuous proton pump inhibitor therapy for high-risk bleeding ulcers: a systematic review and meta-analysis.
IMPORTANCE Current guidelines recommend an intravenous bolus dose of a proton pump inhibitor (PPI) followed by continuous PPI infusion after endoscopic therapy in patients with high-risk bleeding ulcers. Substitution of intermittent PPI therapy, if similarly effective as bolus plus continuous-infusion PPI therapy, would decrease the PPI dose, costs, and resource use. OBJECTIVE To compare inte...
متن کاملCost-effectiveness of proton pump inhibitor therapy for acute peptic ulcer-related bleeding.
OBJECTIVE The purpose of this investigation was to perform a cost-effectiveness analysis of adjunctive oral and intravenous proton pump inhibitor (PPI) therapies for patients with acute peptic ulcer-related bleeding of sufficient severity to warrant hospitalization. DESIGN Cost-effectiveness investigation. Four clinical scenarios were considered: scenario 1, diagnostic endoscopy with oral PPI...
متن کاملAddition of clidinium-C to the 14-day proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication
Background: Triple therapy with a proton pump inhibitor and two antibiotics in Helicobacter pylori (HP) eradication is widely accepted, but this combination fails in a considerable number of cases. The aim of this study was to assess the effect of clidinium-C addition on HP eradication and to investigate the efficacy and safety of clidinium-C in prevention of drugs' side effects. Methods: A ...
متن کاملComparison of Oral and Intravenous Proton Pump Inhibitor on Patients with High Risk Bleeding Peptic Ulcers: A Prospective, Randomized, Controlled Clinical Trial
BACKGROUND Proton pump inhibitors (PPIs) decrease the rate of rebleeding following endoscopic hemostatic therapy in patients with bleeding peptic ulcers. This study compares the efficacy of oral omeprazole vs intravenous pantoprazole in decrease of rebleeding of peptic ulcer patients. METHODS One hundred and six patients with high risk peptic ulcer were randomized to receive either oral omepr...
متن کاملSystematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding.
OBJECTIVES To review randomised controlled trials of treatment with a proton pump inhibitor in patients with ulcer bleeding and determine the impact on mortality, rebleeding, and surgical intervention. DESIGN Systematic review and meta-analysis. DATA SOURCES Cochrane Collaboration's trials register, Medline, and Embase, handsearched abstracts, and pharmaceutical companies. REVIEW METHODS ...
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ژورنال
عنوان ژورنال: JAMA Internal Medicine
سال: 2014
ISSN: 2168-6106
DOI: 10.1001/jamainternmed.2014.4056